Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt
|Research Group Leader
Germany
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Kamyar Hadian
Work
Publications
Erratum: Author Correction: Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening (Nature communications (2024) 15 1 DOI: 10.1038/s41467-024-55226-6.)
Nature communications
journal-article
The metabolic code of ferroptosis: nutritional regulators of cell death
Trends in Biochemical Sciences
journal-article
Scalable and universal prediction of cellular phenotypes
bioRxiv
other
Cyclosporine A in children with ABCA3 deficiency
Pediatric Pulmonology
journal-article
Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism
Molecular Cell
journal-article
Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening
Nature Communications
journal-article
Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of Action
JACS Au
journal-article
Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development
Nature Communications
journal-article
Seratrodast inhibits ferroptosis by suppressing lipid peroxidation
Cell Death and Disease
journal-article
Scalable and universal prediction of cellular phenotypes enables in silico experiments
preprint
The therapeutic potential of targeting regulated non-apoptotic cell death
Nature Reviews Drug Discovery
journal-article
ABCA3 Deficiency—Variant-Specific Response to Hydroxychloroquine
International Journal of Molecular Sciences
journal-article
CellDeathPred: A Deep Learning framework for Ferroptosis and Apoptosis prediction based on cell painting
bioRxiv
other
CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting
Cell Death Discovery
journal-article
CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting
Cell Death Discovery
journal-article
Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis
Nature Communications
journal-article
Reliability of High-Quantity Human Brain Organoids for Modeling Microcephaly, Glioma Invasion, and Drug Screening
SSRN
other
Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion, and drug screening
bioRxiv
other
Suppression of ferroptosis by vitamin A or antioxidants is essential for neuronal development
bioRxiv
other
The therapeutic potential of targeting regulated non-apoptotic cell death
Nature Reviews Drug Discovery
journal-article
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma
European Journal of Medicinal Chemistry
journal-article
Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining
ACS Chemical Biology
journal-article
Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining
ACS Chemical Biology
journal-article
Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development
Nature Structural & Molecular Biology
journal-article
Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development (Nature Structural & Molecular Biology, (2021), 28, 6, (521-532), 10.1038/s41594-021-00590-w)
Nature Structural and Molecular Biology
journal-article
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses
Cell Chemical Biology
journal-article
Farnesoid X Receptor suppresses lipid peroxidation and ferroptosis
bioRxiv
other
High-Content Screening Identifies Cyclosporin A as a Novel ABCA3-Specific Molecular Corrector
American Journal of Respiratory Cell and Molecular Biology
journal-article
Highly Accurate Filters to Flag Frequent Hitters in AlphaScreen Assays by Suggesting their Mechanism
Molecular Informatics
journal-article
Methods to Detect Small Molecule Inhibition of RING E3 Ligase Activity
Current Protocols
journal-article
Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma
Scientific Reports
journal-article
Unleashing high content screening in hit detection – Benchmarking AI workflows including novelty detection
Computational and Structural Biotechnology Journal
journal-article
Vaccination versus SARS-CoV-2 Omicron: three vaccine doses win the battle
Signal Transduction and Targeted Therapy
journal-article
Vaccination versus SARS-CoV-2 Omicron: three vaccine doses win the battle
Signal Transduction and Targeted Therapy
journal-article
Inhalational Anesthetics Do Not Deteriorate Amyloid-β-Derived Pathophysiology in Alzheimer's Disease: Investigations on the Molecular, Neuronal, and Behavioral Level
Journal of Alzheimer's Disease
journal-article
Nuisance compounds in cellular assays
Cell Chemical Biology
journal-article
A roadmap to creating ferroptosis-based medicines
Nature Chemical Biology
journal-article
A roadmap to creating ferroptosis-based medicines
Nature Chemical Biology
journal-article
Brief Guide: Experimental Strategies for High-Quality Hit Selection from Small-Molecule Screening Campaigns
SLAS Discovery
journal-article
Brief Guide: Experimental Strategies for High-Quality Hit Selection from Small-Molecule Screening Campaigns
SLAS Discovery
journal-article
Retinoic acid signaling is critical during the totipotency window in early mammalian development
Nature Structural & Molecular Biology
journal-article
Retinoic acid signaling is critical during the totipotency window in early mammalian development
Nature Structural and Molecular Biology
journal-article
A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation
British Journal of Pharmacology
journal-article
Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses
bioRxiv
other
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3
Cell Stem Cell
journal-article
Cilium induction triggers differentiation of glioma stem cells
Cell Reports
journal-article
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism
EMBO Molecular Medicine
journal-article
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics
Science Advances
journal-article
Studying OTUD6B-OTUB1 Protein–Protein Interaction by Low-Throughput GFP-Trap Assays and High-Throughput AlphaScreen Assays
Methods in Molecular Biology
book-chapter
Erratum: Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3 (Cell Stem Cell (2021) 28(9) (1566–1581.e8), (S1934590921001661), (10.1016/j.stem.2021.04.009))
Cell Stem Cell
journal-article
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly
Nature Communications
journal-article
GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
ACS Central Science
journal-article
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly
Nature Communications
journal-article
Cilium induction triggers differentiation of glioma stem cells
bioRxiv
other
Image-based high-content screening in drug discovery
Drug Discovery Today
journal-article
Image-based high-content screening in drug discovery
Drug Discovery Today
journal-article
Ferroptosis Suppressor Protein 1 (FSP1) and Coenzyme Q10 Cooperatively Suppress Ferroptosis
Biochemistry
journal-article
Ferroptosis Suppressor Protein 1 (FSP1) and Coenzyme Q10 Cooperatively Suppress Ferroptosis
Biochemistry
journal-article
Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis
Scientific Reports
journal-article
Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis
Scientific Reports
journal-article
Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces
Nature Communications
journal-article
SnapShot: Ferroptosis
Cell
journal-article
Structure-Activity Relationship in Pyrazolo[4,3- c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity
Journal of Medicinal Chemistry
journal-article
Transferrin Receptor Is a Specific Ferroptosis Marker
Cell Reports
journal-article
Viral DNA binding protein SUMOylation promotes PML nuclear body localization next to viral replication centers
mBio
journal-article
Inhibition of CPAP–tubulin interaction prevents proliferation of centrosome-amplified cancer cells
EMBO Journal
journal-article
Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans
Journal of cell science
journal-article
A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor
Journal of Biological Chemistry
journal-article
A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor
Journal of Biological Chemistry
journal-article
E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene Expression
Journal of virology
journal-article
Luciferase Advisor: High-Accuracy Model to Flag False Positive Hits in Luciferase HTS Assays
Journal of Chemical Information and Modeling
journal-article
Reducing Mutant Huntingtin Protein Expression in Living Cells by a Newly Identified RNA CAG Binder
ACS Chemical Neuroscience
journal-article
Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity
Journal of Biological Chemistry
journal-article
An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system
Scientific Reports
journal-article
An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system
Scientific Reports
journal-article
Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites
Science
journal-article
Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites
Science
journal-article
A high-content small molecule screen identifies novel inducers of definitive endoderm
Molecular Metabolism
journal-article
A high-throughput screening strategy for development of RNF8-Ubc13 protein-protein interaction inhibitors
SLAS Discovery
journal-article
YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB
eLife
journal-article
A multiplexed high-content screening approach using the chromobody technology to identify cell cycle modulators in living cells
Journal of Biomolecular Screening
journal-article
Identification of Small-Molecule Frequent Hitters of Glutathione S-Transferase-Glutathione Interaction
Journal of Biomolecular Screening
journal-article
Inhibition of Canonical NF-κ B Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction
Scientific Reports
journal-article
Meet our editorial board member
Combinatorial Chemistry and High Throughput Screening
journal-article
Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation
Scientific Reports
journal-article
Three-dimensional microtissues essentially contribute to preclinical validations of therapeutic targets in breast cancer
Cancer Medicine
journal-article
A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment
BMC Cancer
journal-article
Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling
Assay and Drug Development Technologies
journal-article
In Vitro Detection of NEMO–Ubiquitin Binding using Delfia and Microscale Thermophoresis Assays
Methods in Molecular Biology
book
Modulation of human endogenous retrovirus (HERV) transcription during persistent and de novo HIV-1 infection
Retrovirology
journal-article
New small molecules targeting apoptosis and cell viability in osteosarcoma
PLoS ONE
journal-article
Identification of small-molecule frequent hitters from alphascreen high-throughput screens
Journal of Biomolecular Screening
journal-article
Protein-protein interaction modulator drug discovery: Past efforts and future opportunities using a rich source of low- and high-throughput screening assays
Expert Opinion on Drug Discovery
journal-article
Small molecule screening at helmholtz zentrum münchen - from biology to molecules
Combinatorial Chemistry and High Throughput Screening
journal-article
Heterogenous nuclear ribonucleoprotein Q increases protein expression from HIV-1 Rev-dependent transcripts
Virology Journal
journal-article
The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO
Molecular Cell
journal-article
Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL
Cancer Cell
journal-article
Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation
EMBO Journal
journal-article
NF-κB essential modulator (NEMO) interaction with linear and Lys-63 ubiquitin chains contributes to NF-κB activation
Journal of Biological Chemistry
journal-article
Signals from the nucleus: Activation of NF-κB by cytosolic ATM in the DNA damage response
Science Signaling
journal-article
Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp)
AIDS
journal-article
Ubiquitin conjugation and deconjugation in nf-κb signaling
Sub-Cellular Biochemistry
journal-article
Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV rev protein
Journal of Biological Chemistry
journal-article
The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2
Nature Cell Biology
journal-article
Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging
Experimental Cell Research
journal-article
Live-cell assay for simultaneous monitoring of expression and interaction of proteins
BioTechniques
journal-article
The periplasmic E. coli chaperone Skp is a trimer in solution: Biophysical and preliminary crystallographic characterization
Biological Chemistry
journal-article